Lung Cancer Screening Optimization in the U.S.

A multisite research center studying the delivery of lung cancer screening and associated outcomes, with particular interest in:

conducting observational studies in care delivery systems

eliminating disparities in deaths from lung cancer

optimizing benefits & reducing harms of screening



To identify and address critical evidence gaps and enable the delivery of evidence-based interventions to reduce the burden of lung cancer in community settings through:


Of multi-level (patient, facility, system & societal) factors that affect lung cancer screening.


Of lung cancer screening processes including uptake, adherence, risk assessment, diagnostic accuracy, receipt of treatment, and outcomes.


Of patients, clinicians and other stakeholders in research.


Of findings with internal and external collaborators to increase the impact of LOTUS to improve health outcomes.

LOTUS Data Sites

LOTUS is comprised of five US integrated healthcare systems representing diverse populations and communities. The research team includes investigators in each healthcare system as well as Harvard and University of Michigan.

LOTUS (Lung Cancer Screening Optimization in the United States) is one of three research centers in the National Cancer Institute-funded Population-Based Research Optimizing Screening through Personalized Regimens (PROSPR) consortium.

Learn more about LOTUS
data sites

Collaborating Institutions

Henry Ford logo
Kaiser Permanente logo
Marshfield logo
U Penn logo